PRRT2 modulates presynaptic Ca(2+) influx by interacting with P/Q-type channels

Loss-of-function mutations in proline-rich transmembrane protein-2 (PRRT2) cause paroxysmal disorders associated with defective Ca(2+) dependence of glutamatergic transmission. We find that either acute or constitutive PRRT2 deletion induces a significant decrease in the amplitude of evoked excitato...

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Detalles Bibliográficos
Autores principales: Ferrante, Daniele, Sterlini, Bruno, Prestigio, Cosimo, Marte, Antonella, Corradi, Anna, Onofri, Franco, Tortarolo, Giorgio, Vicidomini, Giuseppe, Petretto, Andrea, Muià, Jessica, Thalhammer, Agnes, Valente, Pierluigi, Cingolani, Lorenzo A., Benfenati, Fabio, Baldelli, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220258/
https://www.ncbi.nlm.nih.gov/pubmed/34133925
http://dx.doi.org/10.1016/j.celrep.2021.109248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220258/
https://www.ncbi.nlm.nih.gov/pubmed/34133925
http://dx.doi.org/10.1016/j.celrep.2021.109248

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