Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs

Potassium channels are important regulators of cellular homeostasis and targeting these proteins pharmacologically is unveiling important mechanisms in cancer cell biology. Here we demonstrate that pharmacological stimulation of the Kv11.1 potassium channel activity results in mitochondrial reactive...

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Detalles Bibliográficos
Autores principales: Senyuk, Vitalyi, Eskandari, Najmeh, Jiang, Ying, Garcia-Varela, Rebeca, Sundstrom, Rachel, Leanza, Luigi, Peruzzo, Roberta, Burkard, Mark, Minshall, Richard D., Gentile, Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220394/
https://www.ncbi.nlm.nih.gov/pubmed/34147842
http://dx.doi.org/10.1016/j.redox.2021.102030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220394/
https://www.ncbi.nlm.nih.gov/pubmed/34147842
http://dx.doi.org/10.1016/j.redox.2021.102030

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