Cargando…

Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs

Potassium channels are important regulators of cellular homeostasis and targeting these proteins pharmacologically is unveiling important mechanisms in cancer cell biology. Here we demonstrate that pharmacological stimulation of the Kv11.1 potassium channel activity results in mitochondrial reactive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Senyuk, Vitalyi, Eskandari, Najmeh, Jiang, Ying, Garcia-Varela, Rebeca, Sundstrom, Rachel, Leanza, Luigi, Peruzzo, Roberta, Burkard, Mark, Minshall, Richard D., Gentile, Saverio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220394/ https://www.ncbi.nlm.nih.gov/pubmed/34147842 http://dx.doi.org/10.1016/j.redox.2021.102030

Ejemplares similares

Molecular Activation of the Kv11.1 Channel Reprograms EMT in Colon Cancer by Inhibiting TGFβ Signaling via Activation of Calcineurin
por: Eskandari, Najmeh, et al.
Publicado: (2021)

Pharmacological Activation of Potassium Channel Kv11.1 with NS1643 Attenuates Triple Negative Breast Cancer Cell Migration by Promoting the Dephosphorylation of Caveolin-1
por: Jiang, Ying, et al.
Publicado: (2022)

Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours
por: Fusco, P., et al.
Publicado: (2019)

Can molecular projected density of states (PDOS) be systematically used in electronic conductance analysis?
por: Rangel, Tonatiuh, et al.
Publicado: (2015)

Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer
por: Fukushiro-Lopes, Daniela F., et al.
Publicado: (2017)

hERG1/Kv11.1 activation stimulates transcription of p21(waf/cip) in breast cancer cells via a calcineurin-dependent mechanism
por: Perez-Neut, Mathew, et al.
Publicado: (2015)

Blockade of TNFα to Improve Human CD34+ Cell Repopulating Activity in Allogeneic Stem Cell Transplantation
por: Senyuk, Vitalyi, et al.
Publicado: (2019)

The Oncoprotein EVI1 and the DNA Methyltransferase Dnmt3 Co-Operate in Binding and De Novo Methylation of Target DNA
por: Senyuk, Vitalyi, et al.
Publicado: (2011)

A novel mitochondrial Kv1.3–caveolin axis controls cell survival and apoptosis
por: Capera, Jesusa, et al.
Publicado: (2021)

Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer
por: Okamoto, Takuya, et al.
Publicado: (2021)

Repurposing Kir6/SUR2 Channel Activator Minoxidil to Arrests Growth of Gynecologic Cancers
por: Fukushiro-Lopes, Daniela, et al.
Publicado: (2020)

Regulation of Kv11.1 Isoform Expression by Polyadenylate Binding Protein Nuclear 1
por: Stump, Matthew R., et al.
Publicado: (2021)

Mapping Genetically Compensatory Pathways from Synthetic Lethal Interactions in Yeast
por: Ma, Xiaotu, et al.
Publicado: (2008)

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels
por: Perry, Matthew D., et al.
Publicado: (2013)

Speculative assessment, molecular composition, PDOS, topology exploration (ELF, LOL, RDG), ligand-protein interactions, on 5-bromo-3-nitropyridine-2-carbonitrile
por: Arulaabaranam, K., et al.
Publicado: (2021)

Mutation-Specific Differences in Kv7.1 (KCNQ1) and Kv11.1 (KCNH2) Channel Dysfunction and Long QT Syndrome Phenotypes
por: Kekenes-Huskey, Peter M., et al.
Publicado: (2022)

MEKK1 Regulates Chemokine Expression in Mammary Fibroblasts: Implications for the Breast Tumor Microenvironment
por: Gentile, Saverio, et al.
Publicado: (2021)

Functional characterization of Kv11.1 (hERG) potassium channels split in the voltage-sensing domain
por: de la Peña, Pilar, et al.
Publicado: (2018)

Overcoming selection bias in synthetic lethality prediction
por: Seale, Colm, et al.
Publicado: (2022)

Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy
por: Zhang, Hua, et al.
Publicado: (2022)

miR-9 upregulation leads to inhibition of erythropoiesis by repressing FoxO3
por: Zhang, Yunyuan, et al.
Publicado: (2018)

Patient Derived Organoids (PDOs), Extracellular Matrix (ECM), Tumor Microenvironment (TME) and Drug Screening: State of the Art and Clinical Implications of Ovarian Cancer Organoids in the Era of Precision Medicine
por: Spagnol, Giulia, et al.
Publicado: (2023)

Large-scale Mutational Analysis of Kv11.1 Reveals Molecular Insights into Type 2 Long QT Syndrome
por: Anderson, Corey L., et al.
Publicado: (2014)

Key role for Kv11.1 (ether‐a‐go‐go related gene) channels in rat bladder contractility
por: Barrese, Vincenzo, et al.
Publicado: (2023)

Effect of Si(111) Surface Modification by Ga Focused Ion Beam at 30 kV on GaAs Nanowire Growth
por: Shandyba, Nikita, et al.
Publicado: (2022)

Klaviersonaten, KV 310, KV 333, KV 545
por: Mozart, Wolfgang Amadeus, 1756-1791
Publicado: (1989)

Marizomib irreversibly inhibits proteasome to overcome compensatory hyperactivation in multiple myeloma and solid tumour patients
por: Levin, Nancy, et al.
Publicado: (2016)

Density-Dependent Compensatory Growth in Brown Trout (Salmo trutta) in Nature
por: Sundström, L. Fredrik, et al.
Publicado: (2013)

Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders
por: Bocksteins, Elke
Publicado: (2016)

Multiple mechanisms for overcoming lethal over‐initiation of DNA replication
por: Anderson, Mary E., et al.
Publicado: (2022)

The Schizophrenia-Associated Kv11.1-3.1 Isoform Results in Reduced Current Accumulation during Repetitive Brief Depolarizations
por: Heide, Juliane, et al.
Publicado: (2012)

Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands
por: Hunter, Cheryl, et al.
Publicado: (2010)

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells
por: Leanza, Luigi, et al.
Publicado: (2012)

Overcoming Compensatory Mechanisms toward Chronic Drug Administration to Ensure Long-Term, Sustainable Beneficial Effects
por: Ilan, Yaron
Publicado: (2020)

Impact of intracellular ion channels on cancer development and progression
por: Peruzzo, Roberta, et al.
Publicado: (2016)

Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin
por: Hartung, Franziska, et al.
Publicado: (2016)

C-Terminal β9-Strand of the Cyclic Nucleotide-Binding Homology Domain Stabilizes Activated States of Kv11.1 Channels
por: Ng, Chai Ann, et al.
Publicado: (2013)

Gating mechanism of Kv11.1 (hERG) K(+) channels without covalent connection between voltage sensor and pore domains
por: de la Peña, Pilar, et al.
Publicado: (2017)

Visualizing Mutation-Specific Differences in the Trafficking-Deficient Phenotype of Kv11.1 Proteins Linked to Long QT Syndrome Type 2
por: Hall, Allison R., et al.
Publicado: (2018)

Relative positioning of Kv11.1 (hERG) K(+) channel cytoplasmic domain-located fluorescent tags toward the plasma membrane
por: Barros, Francisco, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_65fdsokspb4ijlf0q8emgjdaqq