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Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2
Brr2 is an essential Ski2-like RNA helicase that exhibits a unique structure among the spliceosomal helicases. Brr2 harbors a catalytically active N-terminal helicase cassette and a structurally similar but enzymatically inactive C-terminal helicase cassette connected by a linker region. Both casset...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220420/ https://www.ncbi.nlm.nih.gov/pubmed/34048711 http://dx.doi.org/10.1016/j.jbc.2021.100829 |