Long-range allostery mediates cooperative adenine nucleotide binding by the Ski2-like RNA helicase Brr2

Brr2 is an essential Ski2-like RNA helicase that exhibits a unique structure among the spliceosomal helicases. Brr2 harbors a catalytically active N-terminal helicase cassette and a structurally similar but enzymatically inactive C-terminal helicase cassette connected by a linker region. Both casset...

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Detalles Bibliográficos
Autores principales: Absmeier, Eva, Vester, Karen, Ghane, Tahereh, Burakovskiy, Dmitry, Milon, Pohl, Imhof, Petra, Rodnina, Marina V., Santos, Karine F., Wahl, Markus C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220420/
https://www.ncbi.nlm.nih.gov/pubmed/34048711
http://dx.doi.org/10.1016/j.jbc.2021.100829

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