High glucose–induced Smad3 linker phosphorylation and CCN2 expression are inhibited by dapagliflozin in a diabetic tubule epithelial cell model

Background: In the kidney glucose is freely filtered by the glomerulus and, mainly, reabsorbed by sodium glucose cotransporter 2 (SGLT2) expressed in the early proximal tubule. Human proximal tubule epithelial cells (PTECs) undergo pathological and fibrotic changes seen in diabetic kidney disease (D...

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Detalles Bibliográficos
Autores principales: Pan, Xinlu, Phanish, Mysore K., Baines, Deborah L., Dockrell, Mark E.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Cell Membranes, Excitation & Transport
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220447/
https://www.ncbi.nlm.nih.gov/pubmed/34003249
http://dx.doi.org/10.1042/BSR20203947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220447/
https://www.ncbi.nlm.nih.gov/pubmed/34003249
http://dx.doi.org/10.1042/BSR20203947

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