The KAG motif of HLA-DRB1 (β71, β74, β86) predicts seroconversion and development of type 1 diabetes

BACKGROUND: HLA-DR4, a common antigen of HLA-DRB1, has multiple subtypes that are strongly associated with risk of type 1 diabetes (T1D); however, some are risk neutral or resistant. The pathobiological mechanism of HLA-DR4 subtypes remains to be elucidated. METHODS: We used a population-based case-...

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Detalles Bibliográficos
Autores principales: Zhao, Lue Ping, Papadopoulos, George K, Lybrand, Terry P., Moustakas, Antonis K., Bondinas, George P., Carlsson, Annelie, Larsson, Helena Elding, Ludvigsson, Johnny, Marcus, Claude, Persson, Martina, Samuelsson, Ulf, Wang, Ruihan, Pyo, Chul-Woo, Nelson, Wyatt C., Geraghty, Daniel E., Rich, Stephen S., Lernmark, Åke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220560/
https://www.ncbi.nlm.nih.gov/pubmed/34153873
http://dx.doi.org/10.1016/j.ebiom.2021.103431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220560/
https://www.ncbi.nlm.nih.gov/pubmed/34153873
http://dx.doi.org/10.1016/j.ebiom.2021.103431

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