IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities

Adoptive immunotherapy using CAR-T cells is a promising curative treatment strategy for hematological malignancies. Current manufacture of clinical-grade CAR-T cells based on lentiviral/retrovirus transfection of T cells followed by anti-CD3/CD28 activation supplemented with IL-2 has been associated...

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Detalles Bibliográficos
Autores principales: Du, Li, Nai, Yaru, Shen, Meiying, Li, Tingting, Huang, Jingjing, Han, Xiaojian, Wang, Wang, Pang, Da, Jin, Aishun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220804/
https://www.ncbi.nlm.nih.gov/pubmed/34179083
http://dx.doi.org/10.3389/fmolb.2021.675179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220804/
https://www.ncbi.nlm.nih.gov/pubmed/34179083
http://dx.doi.org/10.3389/fmolb.2021.675179

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