Directed regioselective ortho,ortho′-magnesiations of aromatics and heterocycles using sBu(2)Mg in toluene

Aryl azoles are ubiquitous as bioactive compounds and their regioselective functionalization is of utmost synthetic importance. Here, we report the development of a toluene-soluble dialkylmagnesium base sBu(2)Mg. This new reagent allows mild and regioselective ortho-magnesiations of various N-arylat...

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Detalles Bibliográficos
Autores principales: Hess, Andreas, Prohaska, Jan P., Doerrich, Sabrina B., Trauner, Florian, Lutter, Ferdinand H., Lemaire, Sébastien, Wagschal, Simon, Karaghiosoff, Konstantin, Knochel, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221067/
https://www.ncbi.nlm.nih.gov/pubmed/34221323
http://dx.doi.org/10.1039/d1sc01777b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221067/
https://www.ncbi.nlm.nih.gov/pubmed/34221323
http://dx.doi.org/10.1039/d1sc01777b

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