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Directed regioselective ortho,ortho′-magnesiations of aromatics and heterocycles using sBu(2)Mg in toluene
Aryl azoles are ubiquitous as bioactive compounds and their regioselective functionalization is of utmost synthetic importance. Here, we report the development of a toluene-soluble dialkylmagnesium base sBu(2)Mg. This new reagent allows mild and regioselective ortho-magnesiations of various N-arylat...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221067/ https://www.ncbi.nlm.nih.gov/pubmed/34221323 http://dx.doi.org/10.1039/d1sc01777b |