Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents

In the present study, two new series of pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety were designed, synthesised, and evaluated for their cytotoxic activity. The benzamide derivatives 16a–e showed higher cytotoxicity than their corresponding Schiff bases 15a–e. Compounds 16a,b,d also inhibited...

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Detalles Bibliográficos
Autores principales: Shawky, Ahmed M., Ibrahim, Nashwa A., Abdalla, Ashraf N., Abourehab, Mohammed A. S., Gouda, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221158/
https://www.ncbi.nlm.nih.gov/pubmed/34154478
http://dx.doi.org/10.1080/14756366.2021.1937618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221158/
https://www.ncbi.nlm.nih.gov/pubmed/34154478
http://dx.doi.org/10.1080/14756366.2021.1937618

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