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Semisynthetic ‘designer’ p53 sheds light on a phosphorylation–acetylation relay

The tumor suppressor protein p53 is a master regulator of cell fate. The activity of p53 is controlled by a plethora of posttranslational modifications (PTMs). However, despite extensive research, the mechanisms of this regulation are still poorly understood due to a paucity of biochemical studies w...

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Detalles Bibliográficos
Autores principales: Margiola, Sofia, Gerecht, Karola, Müller, Manuel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221199/
https://www.ncbi.nlm.nih.gov/pubmed/34221338
http://dx.doi.org/10.1039/d1sc00396h