Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes

Sickle-trait hemoglobin protects against severe Plasmodium falciparum malaria. Severe malaria is governed in part by the expression of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) that are encoded by var genes, specifically those variants that bind Endothelial Protein C Receptor...

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Detalles Bibliográficos
Autores principales: Petersen, Jens E. V., Saelens, Joseph W., Freedman, Elizabeth, Turner, Louise, Lavstsen, Thomas, Fairhurst, Rick M., Diakité, Mahamadou, Taylor, Steve M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221791/
https://www.ncbi.nlm.nih.gov/pubmed/34115805
http://dx.doi.org/10.1371/journal.ppat.1009659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221791/
https://www.ncbi.nlm.nih.gov/pubmed/34115805
http://dx.doi.org/10.1371/journal.ppat.1009659

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