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Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes
Sickle-trait hemoglobin protects against severe Plasmodium falciparum malaria. Severe malaria is governed in part by the expression of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) that are encoded by var genes, specifically those variants that bind Endothelial Protein C Receptor...
Autores principales: | Petersen, Jens E. V., Saelens, Joseph W., Freedman, Elizabeth, Turner, Louise, Lavstsen, Thomas, Fairhurst, Rick M., Diakité, Mahamadou, Taylor, Steve M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221791/ https://www.ncbi.nlm.nih.gov/pubmed/34115805 http://dx.doi.org/10.1371/journal.ppat.1009659 |
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