Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G(4)C(2) RNA in a cellular model

The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G(4)C(2) repeat expansion in the C9orf72 gene. This expansion gives rise to translation of aggregating dipeptide repeat (DPR) proteins, including poly-GA as the most abundant species. However, gain of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Frottin, Frédéric, Pérez-Berlanga, Manuela, Hartl, F Ulrich, Hipp, Mark S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221807/
https://www.ncbi.nlm.nih.gov/pubmed/34161229
http://dx.doi.org/10.7554/eLife.62718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221807/
https://www.ncbi.nlm.nih.gov/pubmed/34161229
http://dx.doi.org/10.7554/eLife.62718

Ejemplares similares