Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia

Post-transcriptional gene regulation, including that by RNA binding proteins (RBPs), has recently been described as an important mechanism in cancer. We had previously identified a set of RBPs that were highly dysregulated in B-cell acute lymphoblastic leukemia (B-ALL) with MLL translocations, which...

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Detalles Bibliográficos
Autores principales: Jaiswal, Amit Kumar, Truong, Hellen, Tran, Tiffany M., Lin, Tasha L., Casero, David, Alberti, Michael O., Rao, Dinesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222245/
https://www.ncbi.nlm.nih.gov/pubmed/34162911
http://dx.doi.org/10.1038/s41598-021-92448-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222245/
https://www.ncbi.nlm.nih.gov/pubmed/34162911
http://dx.doi.org/10.1038/s41598-021-92448-w

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