Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is the nuclear envelope (NE). The NE tethers large chromatin domains through interaction with the nuclear lami...

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Detalles Bibliográficos
Autores principales: Kychygina, Anna, Dall’Osto, Marina, Allen, Joshua A. M., Cadoret, Jean-Charles, Piras, Vincent, Pickett, Hilda A., Crabbe, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222272/
https://www.ncbi.nlm.nih.gov/pubmed/34162976
http://dx.doi.org/10.1038/s41598-021-92631-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222272/
https://www.ncbi.nlm.nih.gov/pubmed/34162976
http://dx.doi.org/10.1038/s41598-021-92631-z

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