Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG

The clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 system is a research hotspot in gene therapy. However, the widely used Streptococcus pyogenes Cas9 (WT-SpCas9) requires an NGG protospacer adjacent motif (PAM) for target recognition, thereby restricting targetable disease mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Oura, Seiya, Noda, Taichi, Morimura, Naoko, Hitoshi, Seiji, Nishimasu, Hiroshi, Nagai, Yoshitaka, Nureki, Osamu, Ikawa, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222283/
https://www.ncbi.nlm.nih.gov/pubmed/34163001
http://dx.doi.org/10.1038/s42003-021-02304-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222283/
https://www.ncbi.nlm.nih.gov/pubmed/34163001
http://dx.doi.org/10.1038/s42003-021-02304-w

Ejemplares similares