The adaptive landscape of a metallo-enzyme is shaped by environment-dependent epistasis

Enzymes can evolve new catalytic activity when environmental changes present them with novel substrates. Despite this seemingly straightforward relationship, factors other than the direct catalytic target can also impact adaptation. Here, we characterize the catalytic activity of a recently evolved...

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Detalles Bibliográficos
Autores principales: Anderson, Dave W., Baier, Florian, Yang, Gloria, Tokuriki, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222346/
https://www.ncbi.nlm.nih.gov/pubmed/34162839
http://dx.doi.org/10.1038/s41467-021-23943-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222346/
https://www.ncbi.nlm.nih.gov/pubmed/34162839
http://dx.doi.org/10.1038/s41467-021-23943-x

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