Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop

Cancer stem cells (CSCs) are regarded as essential targets to overcome tumor progression and therapeutic resistance; however, practical targeting approaches are limited. Here, we identify testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lun...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, In-Gyu, Lee, Jei-Ha, Kim, Seo-Yeon, Heo, Chang-Kyu, Kim, Rae-Kwon, Cho, Eun-Wie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222406/
https://www.ncbi.nlm.nih.gov/pubmed/34163000
http://dx.doi.org/10.1038/s42003-021-02303-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222406/
https://www.ncbi.nlm.nih.gov/pubmed/34163000
http://dx.doi.org/10.1038/s42003-021-02303-x

Ejemplares similares