Cargando…

SCR7, a potent cancer therapeutic agent and a biochemical inhibitor of nonhomologous DNA end‐joining

BACKGROUND: DNA double‐strand breaks (DSBs) are harmful to the cell as it could lead to genomic instability and cell death when left unrepaired. Homologous recombination and nonhomologous end‐joining (NHEJ) are two major DSB repair pathways, responsible for ensuring genome integrity in mammals. Ther...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manjunath, Meghana, Choudhary, Bibha, Raghavan, Sathees C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222562/ https://www.ncbi.nlm.nih.gov/pubmed/33496064 http://dx.doi.org/10.1002/cnr2.1341

Ejemplares similares

Nonhomologous DNA End Joining in Cell-Free Extracts
por: Sharma, Sheetal, et al.
Publicado: (2010)

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions
por: Tadi, Satish Kumar, et al.
Publicado: (2016)

The Minimal Bacillus subtilis Nonhomologous End Joining Repair Machinery
por: de Vega, Miguel
Publicado: (2013)

Evolutionary and Comparative Analysis of Bacterial Nonhomologous End Joining Repair
por: Sharda, Mohak, et al.
Publicado: (2020)

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?
por: Strande, Natasha Tiffany, et al.
Publicado: (2012)

A noncatalytic function of the ligation complex during nonhomologous end joining
por: Cottarel, Jessica, et al.
Publicado: (2013)

Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining
por: Tsai, Chun J., et al.
Publicado: (2013)

Reconstitution of Mycobacterium marinum Nonhomologous DNA End Joining Pathway in Leishmania
por: Zhang, Wen-Wei, et al.
Publicado: (2022)

The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining
por: Waters, Crystal A., et al.
Publicado: (2014)

Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination
por: Du, Likun, et al.
Publicado: (2008)

Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage
por: Pavlicek, Adam, et al.
Publicado: (2006)

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
por: Di Virgilio, Michela, et al.
Publicado: (2005)

Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining
por: Hendrickson, Cynthia L., et al.
Publicado: (2010)

Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts
por: Gassman, Natalie R., et al.
Publicado: (2012)

Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins
por: de Ory, Ana, et al.
Publicado: (2014)

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining
por: Keka, Islam Shamima, et al.
Publicado: (2015)

A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis
por: Löbrich, Markus, et al.
Publicado: (2017)

Causes and Effects of Loss of Classical Nonhomologous End Joining Pathway in Parasitic Eukaryotes
por: Nenarokova, Anna, et al.
Publicado: (2019)

Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell
por: Hussain, Suleman S, et al.
Publicado: (2021)

End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
por: Davis, Bryan J., et al.
Publicado: (2008)

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?
por: Weterings, Eric, et al.
Publicado: (2007)

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
por: Couto, C. Anne-Marie, et al.
Publicado: (2011)

Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining
por: Ochi, Takashi, et al.
Publicado: (2010)

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways
por: Beck, Carole, et al.
Publicado: (2014)

LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining
por: Lawrence, Katherine S., et al.
Publicado: (2016)

Non-homologous End Joining Inhibitor SCR-7 to Exacerbate Low-dose Doxorubicin Cytotoxicity in HeLa Cells
por: Kumar, Ajay, et al.
Publicado: (2017)

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
por: Reid, Dylan A., et al.
Publicado: (2017)

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes
por: Saribasak, Huseyin, et al.
Publicado: (2011)

ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells
por: Adams, Bret R., et al.
Publicado: (2010)

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation
por: Simsek, Deniz, et al.
Publicado: (2011)

BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability
por: Han, Jinhua, et al.
Publicado: (2017)

The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms
por: Garvin, Alexander J., et al.
Publicado: (2019)

A CRISPR-Assisted Nonhomologous End-Joining Strategy for Efficient Genome Editing in Mycobacterium tuberculosis
por: Yan, Mei-Yi, et al.
Publicado: (2020)

Inhibition of nonhomologous end joining‐mediated DNA repair enhances anti‐HBV CRISPR therapy
por: Murai, Kazuhiro, et al.
Publicado: (2022)

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
por: Han, Li, et al.
Publicado: (2008)

Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV–deficient B cells
por: Han, Li, et al.
Publicado: (2008)

The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line
por: Muraki, Keiko, et al.
Publicado: (2013)

TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer
por: Banerjee, Rajat, et al.
Publicado: (2014)

CRISPR/Cas9-Induced Double-Strand Break Repair in Arabidopsis Nonhomologous End-Joining Mutants
por: Shen, Hexi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l1rqg84imefl8rl44qllcio9v8