Cargando…

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir

In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open conformation. The structure of this channel has been p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fagnen, Charline, Bannwarth, Ludovic, Zuniga, Dania, Oubella, Iman, De Zorzi, Rita, Forest, Eric, Scala, Rosa, Guilbault, Samuel, Bendahhou, Saïd, Perahia, David, Vénien-Bryan, Catherine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222812/ https://www.ncbi.nlm.nih.gov/pubmed/34179097 http://dx.doi.org/10.3389/fmolb.2021.691901

Ejemplares similares

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain
por: Fagnen, Charline, et al.
Publicado: (2021)

New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies
por: Fagnen, Charline, et al.
Publicado: (2020)

Cryo–electron microscopy unveils unique structural features of the human Kir2.1 channel
por: Fernandes, Carlos A. H., et al.
Publicado: (2022)

Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains
por: Zubcevic, Lejla, et al.
Publicado: (2014)

Structure of a KirBac potassium channel with an open bundle-crossing indicates a mechanism of channel gating
por: Bavro, Vassiliy N., et al.
Publicado: (2012)

Simulating PIP(2)-Induced Gating Transitions in Kir6.2 Channels
por: Bründl, Michael, et al.
Publicado: (2021)

Ion currents through Kir potassium channels are gated by anionic lipids
por: Jin, Ruitao, et al.
Publicado: (2022)

H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels
por: Rapedius, Markus, et al.
Publicado: (2007)

Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels
por: Shang, Lijun, et al.
Publicado: (2007)

Permeant Ion-Dependent Changes in Gating of Kir2.1 Inward Rectifier Potassium Channels
por: Lu, Tao, et al.
Publicado: (2001)

Water Accessibility Refinement of the Extended Structure of KirBac1.1 in the Closed State
por: Amani, Reza, et al.
Publicado: (2021)

Editorial: Integrative Structural Biology of Proteins and Macromolecular Assemblies: Bridging Experiments and Simulations
por: Batista, Paulo Ricardo, et al.
Publicado: (2022)

Discovery, Characterization, and Structure–Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1
por: Raphemot, Rene, et al.
Publicado: (2011)

Phosphoinositide regulation of inward rectifier potassium (Kir) channels
por: Fürst, Oliver, et al.
Publicado: (2014)

Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling
por: Dudas, Balint, et al.
Publicado: (2020)

Structural rearrangements underlying ligand-gating in Kir channels
por: Wang, Shizhen, et al.
Publicado: (2012)

A Kir6.2 Pore Mutation Causes Inactivation of ATP-Sensitive Potassium Channels by Disrupting PIP(2)-Dependent Gating
por: Bushman, Jeremy D., et al.
Publicado: (2013)

KirBac1.1: It's an Inward Rectifying Potassium Channel
por: Cheng, Wayland W.L., et al.
Publicado: (2009)

Autoantibodies to Potassium Channel KIR4.1 in Multiple Sclerosis
por: Schneider, Raphael
Publicado: (2013)

The epithelial potassium channel Kir7.1 is stimulated by progesterone
por: Björkgren, Ida, et al.
Publicado: (2021)

Molecular Dynamics Simulations of KirBac1.1 Mutants Reveal Global Gating Changes of Kir Channels
por: Linder, Tobias, et al.
Publicado: (2015)

Multi-Omics Approaches to Improve Mitochondrial Disease Diagnosis: Challenges, Advances, and Perspectives
por: Labory, Justine, et al.
Publicado: (2020)

Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus
por: Czigleczki, Janka, et al.
Publicado: (2023)

A benzopyran with antiarrhythmic activity is an inhibitor of Kir3.1-containing potassium channels
por: Cui, Meng, et al.
Publicado: (2021)

Control of Kir channel gating by cytoplasmic domain interface interactions
por: Borschel, William F., et al.
Publicado: (2017)

Expression of Kir4.1 and Kir5.1 inwardly rectifying potassium channels in oligodendrocytes, the myelinating cells of the CNS
por: Brasko, C., et al.
Publicado: (2016)

ESCRT regulates surface expression of the Kir2.1 potassium channel
por: Kolb, Alexander R., et al.
Publicado: (2014)

A constricted opening in Kir channels does not impede potassium conduction
por: Black, Katrina A., et al.
Publicado: (2020)

Inwardly Rectifying Potassium Channel Kir2.1 and its “Kir-ious” Regulation by Protein Trafficking and Roles in Development and Disease
por: Hager, Natalie A., et al.
Publicado: (2022)

Structure and Gating Dynamics of Na(+)/Cl(–) Coupled Neurotransmitter Transporters
por: Joseph, Deepthi, et al.
Publicado: (2019)

Unveiling the Gating Mechanism of CRAC Channel: A Computational Study
por: Guardiani, Carlo, et al.
Publicado: (2021)

Insights into the structural nature of the transition state in the Kir channel gating pathway
por: Fowler, Philip W, et al.
Publicado: (2014)

Unexpected decrease of full-length prion protein in macaques inoculated with prion-contaminated blood products
por: Jaffré, Nina, et al.
Publicado: (2023)

Inwardly rectifying potassium channels (Kir) in central nervous system glia: a special role for Kir4.1 in glial functions
por: Butt, Arthur M, et al.
Publicado: (2006)

Sampling of Protein Conformational Space Using Hybrid Simulations: A Critical Assessment of Recent Methods
por: Kaynak, Burak T., et al.
Publicado: (2022)

Unexpected Dynamic Binding May Rescue the Binding Affinity of Rivaroxaban in a Mutant of Coagulation Factor X
por: Zhang, Zhi-Li, et al.
Publicado: (2022)

The Neuroglial Potassium Cycle during Neurotransmission: Role of Kir4.1 Channels
por: Sibille, Jérémie, et al.
Publicado: (2015)

Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide
por: Henn, Matthew C, et al.
Publicado: (2015)

Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis
por: Kinboshi, Masato, et al.
Publicado: (2020)

Computational Investigation of Voltage-Gated Sodium Channel β3 Subunit Dynamics
por: Glass, William G., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fg9cojpb1sd76s58ubmnn33qca