Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator

Muscle ankyrin repeat protein 1 (MARP1) is frequently up-regulated in stressed muscle, but its effect on skeletal muscle function is poorly understood. Here, we focused on its interaction with the titin–N2A element, found in titin’s molecular spring region. We show that MARP1 binds to F-actin, and t...

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Detalles Bibliográficos
Autores principales: van der Pijl, Robbert J., van den Berg, Marloes, van de Locht, Martijn, Shen, Shengyi, Bogaards, Sylvia J.P., Conijn, Stefan, Langlais, Paul, Hooijman, Pleuni E., Labeit, Siegfried, Heunks, Leo M.A., Granzier, Henk, Ottenheijm, Coen A.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222902/
https://www.ncbi.nlm.nih.gov/pubmed/34152365
http://dx.doi.org/10.1085/jgp.202112925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222902/
https://www.ncbi.nlm.nih.gov/pubmed/34152365
http://dx.doi.org/10.1085/jgp.202112925

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