GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer’s disease

Biochemical, pathogenic, and human genetic data confirm that GSAP (γ-secretase activating protein), a selective γ-secretase modulatory protein, plays important roles in Alzheimer’s disease (AD) and Down’s syndrome. However, the molecular mechanism(s) underlying GSAP-dependent pathogenesis remains la...

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Detalles Bibliográficos
Autores principales: Xu, Peng, Chang, Jerry C., Zhou, Xiaopu, Wang, Wei, Bamkole, Michael, Wong, Eitan, Bettayeb, Karima, Jiang, Lu-Lin, Huang, Timothy, Luo, Wenjie, Xu, Huaxi, Nairn, Angus C., Flajolet, Marc, Ip, Nancy Y., Li, Yue-Ming, Greengard, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222926/
https://www.ncbi.nlm.nih.gov/pubmed/34156424
http://dx.doi.org/10.1084/jem.20202446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222926/
https://www.ncbi.nlm.nih.gov/pubmed/34156424
http://dx.doi.org/10.1084/jem.20202446

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