Myc and the Replicative CMG Helicase: The Creation and Destruction of Cancer

Myc-driven tumorigenesis involves a non-transcriptional role for Myc in over-activating replicative Cdc45-MCM-GINS (CMG) helicases. Excessive stimulation of CMG helicases by Myc mismanages CMG function by diminishing the number of reserve CMGs necessary for fidelity of DNA replication and recovery f...

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Detalles Bibliográficos
Autores principales: Reed, Damon R., Alexandrow, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223603/
https://www.ncbi.nlm.nih.gov/pubmed/32080866
http://dx.doi.org/10.1002/bies.201900218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223603/
https://www.ncbi.nlm.nih.gov/pubmed/32080866
http://dx.doi.org/10.1002/bies.201900218

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