Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis

Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole-body insulin receptor haploinsufficiency (Insr(+/-)) against littermate controls, we found impaired limb perfusion and muscle capill...

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Detalles Bibliográficos
Autores principales: Walker, Andrew M N, Warmke, Nele, Mercer, Ben, Watt, Nicole T, Mughal, Romana, Smith, Jessica, Galloway, Stacey, Haywood, Natalie J, Soomro, Taha, Griffin, Kathryn J, Wheatcroft, Stephen B, Yuldasheva, Nadira Y, Beech, David J, Carmeliet, Peter, Kearney, Mark T, Cubbon, Richard M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223729/
https://www.ncbi.nlm.nih.gov/pubmed/34037749
http://dx.doi.org/10.1210/endocr/bqab104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223729/
https://www.ncbi.nlm.nih.gov/pubmed/34037749
http://dx.doi.org/10.1210/endocr/bqab104

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