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RNA Helicase A/DHX9 Forms Unique Cytoplasmic Antiviral Granules That Restrict Oncolytic Myxoma Virus Replication in Human Cancer Cells

RNA helicase A/DHX9 is required for diverse RNA-related essential cellular functions and antiviral responses and is hijacked by RNA viruses to support their replication. Here, we show that during the late replication stage in human cancer cells of myxoma virus (MYXV), a member of the double-stranded...

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Detalles Bibliográficos
Autores principales: Rahman, Masmudur M., Gutierrez-Jensen, Ami D., Glenn, Honor L., Abrantes, Mario, Moussatche, Nissin, McFadden, Grant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223942/
https://www.ncbi.nlm.nih.gov/pubmed/33952639
http://dx.doi.org/10.1128/JVI.00151-21