Lost Small Envelope Protein Expression from Naturally Occurring PreS1 Deletion Mutants of Hepatitis B Virus Is Often Accompanied by Increased HBx and Core Protein Expression as Well as Genome Replication

Hepatitis B virus (HBV) transcribes coterminal mRNAs of 0.7 to 3.5 kb from the 3.2-kb covalently closed circular DNA, with the 2.1-kb RNA being most abundant. The 0.7-kb RNA produces HBx protein, a transcriptional transactivator, while the 3.5-kb pregenomic RNA (pgRNA) drives core and P protein tran...

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Detalles Bibliográficos
Autores principales: Fu, Shuwen, Zhang, Jing, Yuan, Quan, Wang, Qianru, Deng, Qiang, Li, Jisu, Xia, Ningshao, Wang, Yongxiang, Wen, Yumei, Tong, Shuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223946/
https://www.ncbi.nlm.nih.gov/pubmed/33910956
http://dx.doi.org/10.1128/JVI.00660-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223946/
https://www.ncbi.nlm.nih.gov/pubmed/33910956
http://dx.doi.org/10.1128/JVI.00660-21

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