Cargando…

Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease

To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease. It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor (α7-nAChR) and sigma-1 re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vetel, Steven, Foucault-Fruchard, Laura, Tronel, Claire, Buron, Frédéric, Vergote, Jackie, Bodard, Sylvie, Routier, Sylvain, Sérrière, Sophie, Chalon, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224116/ https://www.ncbi.nlm.nih.gov/pubmed/33269756 http://dx.doi.org/10.4103/1673-5374.300451

Ejemplares similares

Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1
por: Foucault-Fruchard, Laura, et al.
Publicado: (2018)

Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson’s Disease Rat Model
por: Sérrière, Sophie, et al.
Publicado: (2015)

Therapeutic potential of α7 nicotinic receptor agonists to regulate neuroinflammation in neurodegenerative diseases
por: Foucault-Fruchard, Laura, et al.
Publicado: (2017)

Oxidative Stress Is Related to the Deleterious Effects of Heme Oxygenase-1 in an In Vivo Neuroinflammatory Rat Model
por: Tronel, Claire, et al.
Publicado: (2013)

Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [(18)F] PET tracer
por: Elie, Jonathan, et al.
Publicado: (2018)

Study of influence of the glutamatergic concentration of [(18)F]FPEB binding to metabotropic glutamate receptor subtype 5 with N-acetylcysteine challenge in rats and SRM/PET study in human healthy volunteers
por: Dupont, Anne-Claire, et al.
Publicado: (2021)

Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis
por: Favrais, Geraldine, et al.
Publicado: (2021)

Expression of Phenotypic Astrocyte Marker Is Increased in a Transgenic Mouse Model of Alzheimer's Disease versus Age-Matched Controls: A Presymptomatic Stage Study
por: Doméné, Aurélie, et al.
Publicado: (2016)

Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [(18)F]DPA-714 PET Imaging
por: Thomas, Clément, et al.
Publicado: (2016)

Modeling Temperature and Species Concentration Profiles on a Continuous-Flow Reactor Applied to Aldol Condensation
por: Chairat, Aziza, et al.
Publicado: (2022)

Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport
por: Lagrue, Emmanuelle, et al.
Publicado: (2010)

Drug Delivery Systems for Imaging and Therapy of Parkinson's Disease
por: Gunay, Mine Silindir, et al.
Publicado: (2016)

The Azaindole Framework in the Design of Kinase Inhibitors
por: Mérour, Jean-Yves, et al.
Publicado: (2014)

Trans ε-Viniferin Decreases Amyloid Deposits With Greater Efficiency Than Resveratrol in an Alzheimer’s Mouse Model
por: Freyssin, Aline, et al.
Publicado: (2022)

Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an α7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson’s Disease Mouse Models
por: Park, Jung-Eun, et al.
Publicado: (2022)

Aminations and arylations by direct C–O activation for the design of 7,8-dihydro-6H-5,8-ethanopyrido[3,2-d]pyrimidines
por: Laurent, Mazarine, et al.
Publicado: (2021)

Performance evaluation of the IRIS XL-220 PET/CT system, a new camera dedicated to non-human primates
por: Boisson, Frédéric, et al.
Publicado: (2022)

30ièmes Journées Franco-Belges de Pharmacochimie
por: Aci-Sèche, Samia, et al.
Publicado: (2016)

Design, Synthesis and the Biological Evaluation of New 1,3-Thiazolidine-4-ones Based on the 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one Scaffold
por: Apotrosoaei, Maria, et al.
Publicado: (2014)

Access and Modulation of Substituted Pyrrolo[3,4-c]pyrazole-4,6-(2H,5H)-diones
por: Ejjoummany, Abdelaziz, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of New 1,3-Thiazolidine-4-one Derivatives of 2-(4-Isobutylphenyl)propionic Acid
por: Vasincu, Ioana Mirela, et al.
Publicado: (2014)

Synthesis of novel series of 3,5-disubstituted imidazo[1,2-d] [1,2,4]thiadiazoles involving S(N)Ar and Suzuki–Miyaura cross-coupling reactions
por: Pescheteau, Clémentine, et al.
Publicado: (2022)

Development of PET Radioligands Targeting COX-2 for Colorectal Cancer Staging, a Review of in vitro and Preclinical Imaging Studies
por: Dagallier, Caroline, et al.
Publicado: (2021)

Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
por: Chaney, Aisling M, et al.
Publicado: (2021)

Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1′,2′:1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions
por: Ejjoummany, Abdelaziz, et al.
Publicado: (2018)

Machine Learning Neuroprotective Strategy Reveals a Unique Set of Parkinson Therapeutic Nicotine Analogs
por: Rojas-Rodríguez, Felipe, et al.
Publicado: (2020)

On the Nature of σ–σ, σ–π, and π–π Stacking in Extended Systems
por: Cabaleiro-Lago, Enrique M., et al.
Publicado: (2018)

Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold
por: Constantin, Sandra, et al.
Publicado: (2017)

The neuroprotective effect of nicotine in Parkinson’s disease models is associated with inhibiting PARP-1 and caspase-3 cleavage
por: Lu, Justin Y.D., et al.
Publicado: (2017)

Alternative σ(I)/anti-σ(I) factors represent a unique form of bacterial σ/anti-σ complex
por: Wei, Zhen, et al.
Publicado: (2019)

The Bifurcated σ-Hole···σ-Hole Stacking Interactions
por: Zhang, Yu, et al.
Publicado: (2022)

Compared benefits of educational programs dedicated to diabetic patients with or without community pharmacist involvement
por: Foucault-Fruchard, Laura, et al.
Publicado: (2020)

Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester
por: Pânzariu, Andreea-Teodora, et al.
Publicado: (2016)

Nicotine receptor partial agonists for smoking cessation
por: Livingstone-Banks, Jonathan, et al.
Publicado: (2023)

Nicotine receptor partial agonists for smoking cessation
por: Livingstone-Banks, Jonathan, et al.
Publicado: (2023)

Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold
por: Sava, Alexandru, et al.
Publicado: (2021)

Potential Benefits of Therapeutic Use of β2-Adrenergic Receptor Agonists in Neuroprotection and Parkinsonμs Disease
por: Peterson, Lynda, et al.
Publicado: (2014)

Evolution of a σ–(c-di-GMP)–anti-σ switch
por: Schumacher, Maria A., et al.
Publicado: (2021)

The Neuroprotective Effects of the CB2 Agonist GW842166x in the 6-OHDA Mouse Model of Parkinson’s Disease
por: Yu, Hao, et al.
Publicado: (2021)

Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress
por: Nourse, J. Brucker, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bvojanoddurfufjl5ioetrdqo2