Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM

Non-homologous end joining (NHEJ) is the preferred pathway for the repair of DNA double-strand breaks in humans. Here we describe three structural aspects of the repair pathway: stages, scaffolds and strings. We discuss the orchestration of DNA repair to guarantee robust and efficient NHEJ. We focus...

Descripción completa

Detalles Bibliográficos
Autores principales: Liang, Shikang, Chaplin, Amanda K., Stavridi, Antonia Kefala, Appleby, Robert, Hnizda, Ales, Blundell, Tom L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224183/
https://www.ncbi.nlm.nih.gov/pubmed/33285184
http://dx.doi.org/10.1016/j.pbiomolbio.2020.11.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224183/
https://www.ncbi.nlm.nih.gov/pubmed/33285184
http://dx.doi.org/10.1016/j.pbiomolbio.2020.11.008

Ejemplares similares