DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A

DNMT3A mutations are frequently identified in acute myeloid leukemia (AML) and indicate poor prognosis. Previously, we found that the hotspot mutation DNMT3A R882H could upregulate CDK1 and induce AML in conditional knock-in mice. However, the mechanism by which CDK1 is involved in leukemogenesis of...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Ying, Dai, Yujun, Yang, Xuejiao, Wu, Songfang, Wang, Yueying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224654/
https://www.ncbi.nlm.nih.gov/pubmed/34067359
http://dx.doi.org/10.3390/biom11060781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224654/
https://www.ncbi.nlm.nih.gov/pubmed/34067359
http://dx.doi.org/10.3390/biom11060781

Ejemplares similares