Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site

Microbial pathogens bind host complement regulatory proteins to evade the immune system. The bacterial pathogen Neisseria meningitidis, or meningococcus, binds several complement regulators, including human Factor H (FH). FH binding protein (FHbp) is a component of two licensed meningococcal vaccine...

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Detalles Bibliográficos
Autores principales: Sands, Nathaniel A., Beernink, Peter T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224966/
https://www.ncbi.nlm.nih.gov/pubmed/34125873
http://dx.doi.org/10.1371/journal.ppat.1009655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8224966/
https://www.ncbi.nlm.nih.gov/pubmed/34125873
http://dx.doi.org/10.1371/journal.ppat.1009655

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