Molecular and Mechanistic Characterization of PddB, the First PLP-Independent 2,4-Diaminobutyric Acid Racemase Discovered in an Actinobacterial D-Amino Acid Homopolymer Biosynthesis

We recently disclosed that the biosynthesis of antiviral γ-poly-D-2,4-diaminobutyric acid (poly-D-Dab) in Streptoalloteichus hindustanus involves an unprecedented cofactor independent stereoinversion of Dab catalyzed by PddB, which shows weak homology to diaminopimelate epimerase (DapF). Enzymologic...

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Detalles Bibliográficos
Autores principales: Yamanaka, Kazuya, Ozaki, Ryo, Hamano, Yoshimitsu, Oikawa, Tadao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225329/
https://www.ncbi.nlm.nih.gov/pubmed/34177872
http://dx.doi.org/10.3389/fmicb.2021.686023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225329/
https://www.ncbi.nlm.nih.gov/pubmed/34177872
http://dx.doi.org/10.3389/fmicb.2021.686023

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