Pharmic Activation of PKG2 Alleviates Diabetes-Induced Osteoblast Dysfunction by Suppressing PLCβ1-Ca(2+)-Mediated Endoplasmic Reticulum Stress

As reported in our previous study, cinaciguat can improve implant osseointegration in type 2 diabetes mellitus (T2DM) rats by reactivating type 2 cGMP-dependent protein kinase (PKG2), but the downstream mechanisms remain unclear. In the present study, we investigated the favorable effect of cinacigu...

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Detalles Bibliográficos
Autores principales: Jia, Tingting, Wang, Ya-nan, Feng, Yao, Wang, Chenchen, Zhang, Dongjiao, Xu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225424/
https://www.ncbi.nlm.nih.gov/pubmed/34221234
http://dx.doi.org/10.1155/2021/5552530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225424/
https://www.ncbi.nlm.nih.gov/pubmed/34221234
http://dx.doi.org/10.1155/2021/5552530

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