Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced mediators of cellular attachment dynamics and extracellular matrix protein production. Here we show that Thbs1, but not Thbs2, Thbs3 or Thbs4, induces lethal cardiac atrophy when overexpressed. Mechani...

Descripción completa

Detalles Bibliográficos
Autores principales: Vanhoutte, Davy, Schips, Tobias G., Vo, Alexander, Grimes, Kelly M., Baldwin, Tanya A., Brody, Matthew J., Accornero, Federica, Sargent, Michelle A., Molkentin, Jeffery D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225674/
https://www.ncbi.nlm.nih.gov/pubmed/34168130
http://dx.doi.org/10.1038/s41467-021-24215-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225674/
https://www.ncbi.nlm.nih.gov/pubmed/34168130
http://dx.doi.org/10.1038/s41467-021-24215-4

Ejemplares similares