Residue 6.43 defines receptor function in class F GPCRs

The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD(1-10)) subtypes and Smoothened (SMO), remains one of the most enigmatic GPCR families. While SMO relies on cholesterol binding to the 7TM core of the receptor to activate downstream signaling, underlying detai...

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Detalles Bibliográficos
Autores principales: Turku, Ainoleena, Schihada, Hannes, Kozielewicz, Pawel, Bowin, Carl-Fredrik, Schulte, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225760/
https://www.ncbi.nlm.nih.gov/pubmed/34168128
http://dx.doi.org/10.1038/s41467-021-24004-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225760/
https://www.ncbi.nlm.nih.gov/pubmed/34168128
http://dx.doi.org/10.1038/s41467-021-24004-z

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