The human nucleoporin Tpr protects cells from RNA-mediated replication stress

Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr depletion generates transcription-dependent replication stress, DNA breaks, and genomic instability. DNA fiber assays and electron microscopy visualization of replication interm...

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Detalles Bibliográficos
Autores principales: Kosar, Martin, Giannattasio, Michele, Piccini, Daniele, Maya-Mendoza, Apolinar, García-Benítez, Francisco, Bartkova, Jirina, Barroso, Sonia I., Gaillard, Hélène, Martini, Emanuele, Restuccia, Umberto, Ramirez-Otero, Miguel Angel, Garre, Massimiliano, Verga, Eleonora, Andújar-Sánchez, Miguel, Maynard, Scott, Hodny, Zdenek, Costanzo, Vincenzo, Kumar, Amit, Bachi, Angela, Aguilera, Andrés, Bartek, Jiri, Foiani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225803/
https://www.ncbi.nlm.nih.gov/pubmed/34168151
http://dx.doi.org/10.1038/s41467-021-24224-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225803/
https://www.ncbi.nlm.nih.gov/pubmed/34168151
http://dx.doi.org/10.1038/s41467-021-24224-3

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