Improved pyrrolysine biosynthesis through phage assisted non-continuous directed evolution of the complete pathway

Pyrrolysine (Pyl, O) exists in nature as the 22(nd) proteinogenic amino acid. Despite being a fundamental building block of proteins, studies of Pyl have been hindered by the difficulty and inefficiency of both its chemical and biological syntheses. Here, we improve Pyl biosynthesis via rational eng...

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Detalles Bibliográficos
Autores principales: Ho, Joanne M. L., Miller, Corwin A., Smith, Kathryn A., Mattia, Jacob R., Bennett, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225853/
https://www.ncbi.nlm.nih.gov/pubmed/34168131
http://dx.doi.org/10.1038/s41467-021-24183-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225853/
https://www.ncbi.nlm.nih.gov/pubmed/34168131
http://dx.doi.org/10.1038/s41467-021-24183-9

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