Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function

OBJECTIVE: Genetic and acquired abnormalities contribute to pancreatic β-cell failure in diabetes. Transcription factors Hnf4α (MODY1) and FoxO1 are respective examples of these two components and act through β-cell-specific enhancers. However, their relationship is unclear. METHODS: In this report,...

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Detalles Bibliográficos
Autores principales: Kuo, Taiyi, Du, Wen, Miyachi, Yasutaka, Dadi, Prasanna K., Jacobson, David A., Segrè, Daniel, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225970/
https://www.ncbi.nlm.nih.gov/pubmed/34048961
http://dx.doi.org/10.1016/j.molmet.2021.101256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8225970/
https://www.ncbi.nlm.nih.gov/pubmed/34048961
http://dx.doi.org/10.1016/j.molmet.2021.101256

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