A Regulatory Loop Involving Notch and Wnt Signaling Maintains Leukemia Stem Cells in T-Cell Acute Lymphoblastic Leukemia

Leukemia-initiating cells play critical role in relapse, resistance to therapies and metastases but the mechanism remains largely elusive. We report that β-catenin is over-expressed in almost all T-ALL patients and flow sorted β-catenin(high) fractions are highly resistant to therapy, leading to liv...

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Detalles Bibliográficos
Autores principales: Zhang, Ling, Wu, Jieying, Feng, Yashu, Khadka, Bijay, Fang, Zhigang, Gu, Jiaming, Tang, Baoqiang, Xiao, Ruozhi, Pan, Guangjin, Liu, Jia-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226090/
https://www.ncbi.nlm.nih.gov/pubmed/34179007
http://dx.doi.org/10.3389/fcell.2021.678544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226090/
https://www.ncbi.nlm.nih.gov/pubmed/34179007
http://dx.doi.org/10.3389/fcell.2021.678544

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