Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders

Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and spectrally characterized. The compounds were further evaluated for their inhibitory potential against monoamine oxidases (MAOs) and β-secretase (BACE-1). Six compounds inhibited MAO-B more effectively than MAO-A, and the...

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Detalles Bibliográficos
Autores principales: Koyiparambath, Vishal Payyalot, Oh, Jong Min, Khames, Ahmed, Abdelgawad, Mohamed A., Nair, Aathira Sujathan, Nath, Lekshmi R., Gambacorta, Nicola, Ciriaco, Fulvio, Nicolotti, Orazio, Kim, Hoon, Mathew, Bijo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226672/
https://www.ncbi.nlm.nih.gov/pubmed/34201128
http://dx.doi.org/10.3390/pharmaceutics13060850

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226672/
https://www.ncbi.nlm.nih.gov/pubmed/34201128
http://dx.doi.org/10.3390/pharmaceutics13060850

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