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Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model

Supplementation of a mother’s diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of fetuses at risk of intrauterine growth restriction. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day...

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Autores principales: Yeste, Natalia, Valent, Daniel, Arroyo, Laura, Vázquez-Gómez, Marta, García-Contreras, Consolación, Pumarola, Martí, González-Bulnes, Antonio, Bassols, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227239/
https://www.ncbi.nlm.nih.gov/pubmed/34073097
http://dx.doi.org/10.3390/antiox10060884
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author Yeste, Natalia
Valent, Daniel
Arroyo, Laura
Vázquez-Gómez, Marta
García-Contreras, Consolación
Pumarola, Martí
González-Bulnes, Antonio
Bassols, Anna
author_facet Yeste, Natalia
Valent, Daniel
Arroyo, Laura
Vázquez-Gómez, Marta
García-Contreras, Consolación
Pumarola, Martí
González-Bulnes, Antonio
Bassols, Anna
author_sort Yeste, Natalia
collection PubMed
description Supplementation of a mother’s diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of fetuses at risk of intrauterine growth restriction. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of total gestational period), and individuals were sampled at three different ages: 100-day-old fetuses and 1-month- and 6-month-old piglets. After euthanasia, the brain was removed and the hippocampus, amygdala, and prefrontal cortex were dissected. The profile of the catecholaminergic and serotoninergic neurotransmitters (NTs) was characterized and an immunohistochemical study of the hippocampus was performed. The results indicated that maternal supplementation with HTX during pregnancy affected the NT profile in a brain-area-dependant mode and it modified the process of neuron differentiation in the hippocampal CA1 and GD areas, indicating that cell differentiation occurred more rapidly in the HTX group. These effects were specific to the fetal period, concomitantly with HTX maternal supplementation, since no major differences remained between the control and treated groups in 1-month- and 6-month-old pigs.
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spelling pubmed-82272392021-06-26 Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model Yeste, Natalia Valent, Daniel Arroyo, Laura Vázquez-Gómez, Marta García-Contreras, Consolación Pumarola, Martí González-Bulnes, Antonio Bassols, Anna Antioxidants (Basel) Article Supplementation of a mother’s diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of fetuses at risk of intrauterine growth restriction. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of total gestational period), and individuals were sampled at three different ages: 100-day-old fetuses and 1-month- and 6-month-old piglets. After euthanasia, the brain was removed and the hippocampus, amygdala, and prefrontal cortex were dissected. The profile of the catecholaminergic and serotoninergic neurotransmitters (NTs) was characterized and an immunohistochemical study of the hippocampus was performed. The results indicated that maternal supplementation with HTX during pregnancy affected the NT profile in a brain-area-dependant mode and it modified the process of neuron differentiation in the hippocampal CA1 and GD areas, indicating that cell differentiation occurred more rapidly in the HTX group. These effects were specific to the fetal period, concomitantly with HTX maternal supplementation, since no major differences remained between the control and treated groups in 1-month- and 6-month-old pigs. MDPI 2021-05-31 /pmc/articles/PMC8227239/ /pubmed/34073097 http://dx.doi.org/10.3390/antiox10060884 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yeste, Natalia
Valent, Daniel
Arroyo, Laura
Vázquez-Gómez, Marta
García-Contreras, Consolación
Pumarola, Martí
González-Bulnes, Antonio
Bassols, Anna
Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
title Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
title_full Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
title_fullStr Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
title_full_unstemmed Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
title_short Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model
title_sort polyphenols and iugr pregnancies: effects of the antioxidant hydroxytyrosol on brain neurochemistry and development in a porcine model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227239/
https://www.ncbi.nlm.nih.gov/pubmed/34073097
http://dx.doi.org/10.3390/antiox10060884
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