Novel N-Arylsulfonylindoles Targeted as Ligands of the 5-HT(6) Receptor. Insights on the Influence of C-5 Substitution on Ligand Affinity

A new series of twenty-two C-5 substituted N-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT(6) receptor affinity. Eleven compounds showed moderate to high affinity at the receptor (K(i) = 58–403 nM), with compound 4d being identified as the most...

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Detalles Bibliográficos
Autores principales: Arrieta-Rodríguez, Loreto, Espinoza-Rosales, Daniela, Vera, Gonzalo, Cho, Young Hwa, Cabezas, David, Vásquez-Velásquez, David, Mella-Raipán, Jaime, Lagos, Carlos F., Recabarren-Gajardo, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227400/
https://www.ncbi.nlm.nih.gov/pubmed/34206083
http://dx.doi.org/10.3390/ph14060528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227400/
https://www.ncbi.nlm.nih.gov/pubmed/34206083
http://dx.doi.org/10.3390/ph14060528

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