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Palbociclib induces cell senescence and apoptosis of gastric cancer cells by inhibiting the Notch pathway

Palbociclib (PD0332991), a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, has been reported to exert anticancer activity in some cancers, including gastric cancer (GC). However, the role of palbociclib in GC remains largely unknown. The present study aimed to investigate the effects of pa...

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Detalles Bibliográficos
Autores principales: Bi, Hengtai, Shang, Juan, Zou, Xiao, Xu, Jing, Han, Yumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227472/
https://www.ncbi.nlm.nih.gov/pubmed/34188705
http://dx.doi.org/10.3892/ol.2021.12864