Cargando…
Palbociclib induces cell senescence and apoptosis of gastric cancer cells by inhibiting the Notch pathway
Palbociclib (PD0332991), a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, has been reported to exert anticancer activity in some cancers, including gastric cancer (GC). However, the role of palbociclib in GC remains largely unknown. The present study aimed to investigate the effects of pa...
Autores principales: | Bi, Hengtai, Shang, Juan, Zou, Xiao, Xu, Jing, Han, Yumei |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227472/ https://www.ncbi.nlm.nih.gov/pubmed/34188705 http://dx.doi.org/10.3892/ol.2021.12864 |
Ejemplares similares
-
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity
por: Pogacar, Ziva, et al.
Publicado: (2022) -
Palbociclib Induces Senescence in Melanoma and Breast Cancer Cells and Leads to Additive Growth Arrest in Combination With Irradiation
por: Jost, Tina, et al.
Publicado: (2021) -
Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence
por: Pandey, Kamal, et al.
Publicado: (2020) -
Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy
por: Cayo, Angel, et al.
Publicado: (2023) -
Inhibition of apoptosis by Notch signalling in breast epithelial cells
por: Meurette, O, et al.
Publicado: (2008)