Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177(®) (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction

Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility and diastolic function. We proposed that OLT1177(®) (dapansutrile), a novel NLRP3 inhibitor, could preserve contractile reserve and diastolic function after myocardial infarction (MI). We used an experimenta...

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Detalles Bibliográficos
Autores principales: Aliaga, Joseph, Bonaventura, Aldo, Mezzaroma, Eleonora, Dhakal, Yogesh, Mauro, Adolfo Gabriele, Abbate, Antonio, Toldo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227554/
https://www.ncbi.nlm.nih.gov/pubmed/34207886
http://dx.doi.org/10.3390/molecules26123534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227554/
https://www.ncbi.nlm.nih.gov/pubmed/34207886
http://dx.doi.org/10.3390/molecules26123534

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