Rational Design of Poly(disulfide)s as a Universal Platform for Delivery of CRISPR-Cas9 Machineries toward Therapeutic Genome Editing

[Image: see text] We synthesized a series of poly(disulfide)s by ring-opening polymerization and demonstrated that the copolymerization of monomer 1 containing diethylenetriamine moieties and monomer 2 containing guanidyl ligands could generate an efficient delivery platform for different forms of C...

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Detalles Bibliográficos
Autores principales: Guo, Jiajing, Wan, Tao, Li, Bowen, Pan, Qi, Xin, Huhu, Qiu, Yayu, Ping, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227594/
https://www.ncbi.nlm.nih.gov/pubmed/34235260
http://dx.doi.org/10.1021/acscentsci.0c01648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227594/
https://www.ncbi.nlm.nih.gov/pubmed/34235260
http://dx.doi.org/10.1021/acscentsci.0c01648

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