Cargando…

Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis

Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of antimicrobial resistance (AMR). Here, we have examined nucleoside analogues (NAs)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sumabe, Balagra Kasim, Ræder, Synnøve Brandt, Røst, Lisa Marie, Sharma, Animesh, Donkor, Eric S., Mosi, Lydia, Duodu, Samuel, Bruheim, Per, Otterlei, Marit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227612/ https://www.ncbi.nlm.nih.gov/pubmed/34198819 http://dx.doi.org/10.3390/biom11060843

Ejemplares similares

Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
por: Nedal, Aina, et al.
Publicado: (2020)

PCNA regulates primary metabolism by scaffolding metabolic enzymes
por: Røst, Lisa M., et al.
Publicado: (2022)

Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization
por: Nepal, Anala, et al.
Publicado: (2021)

Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
por: Singleton, Amanda Holstad, et al.
Publicado: (2023)

Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo
por: Raeder, Synnøve Brandt, et al.
Publicado: (2021)

APIM-Mediated REV3L–PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells
por: Ræder, Synnøve Brandt, et al.
Publicado: (2018)

Nucleoside Analogues as Antibacterial Agents
por: Thomson, Jessica M., et al.
Publicado: (2019)

Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis
por: Qiu, Li, et al.
Publicado: (2018)

Advances in antiviral nucleoside analogues and their prodrugs
por: Seley-Radtke, Katherine, et al.
Publicado: (2018)

Aminoribosylated Analogues of Muraymycin Nucleoside Antibiotics
por: Wiegmann, Daniel, et al.
Publicado: (2018)

Nucleoside analogues for the treatment of coronavirus infections
por: Pruijssers, Andrea J, et al.
Publicado: (2019)

Nucleoside analogues for the treatment of animal trypanosomiasis
por: Mabille, Dorien, et al.
Publicado: (2022)

PrimPol prevents APOBEC/AID family mediated DNA mutagenesis
por: Pilzecker, Bas, et al.
Publicado: (2016)

Characterization of culturable airborne bacteria and antibiotic susceptibility profiles of indoor and immediate-outdoor environments of a research institute in Ghana
por: Abiola, Isawumi, et al.
Publicado: (2018)

Nucleoside Analogues. Chemistry, Biology, and Medical Applications
por: Levinson, Barry L.
Publicado: (1980)

Broad-Spectrum Antiviral Strategies and Nucleoside Analogues
por: Geraghty, Robert J., et al.
Publicado: (2021)

Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors
por: Alexandrova, Liudmila A., et al.
Publicado: (2022)

The effect of sequence context on spontaneous Polζ-dependent mutagenesis in Saccharomyces cerevisiae
por: Abdulovic, Amy L., et al.
Publicado: (2008)

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides
por: Kobayashi, Kaori, et al.
Publicado: (2016)

Synthesis of some novel hydrazono acyclic nucleoside analogues
por: Soltani Rad, Mohammad N, et al.
Publicado: (2010)

Flex-nucleoside analogues – Novel therapeutics against filoviruses
por: Yates, Mary K., et al.
Publicado: (2017)

Synthesis of ribavirin 2’-Me-C-nucleoside analogues
por: Cosson, Fanny, et al.
Publicado: (2017)

N,O‐Nucleoside Analogues: Metabolic and Apoptotic Activity
por: Marraffa, Andrea, et al.
Publicado: (2020)

Synthesis and photophysical characterization of fluorescent indole nucleoside analogues
por: Sawyer, Jacob M., et al.
Publicado: (2023)

The role of PCNA as a scaffold protein in cellular signaling is functionally conserved between yeast and humans
por: Olaisen, Camilla, et al.
Publicado: (2018)

Novel acyclic nucleoside analogues as inhibitors of HIV-1 RT
por: Singh, Anuradha, et al.
Publicado: (2012)

Photochemical Synthesis of Nucleoside Analogues from Cyclobutanones: Bicyclic and Isonucleosides
por: Jaffer, Mileina, et al.
Publicado: (2010)

Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues
por: Papadakis, Georgios, et al.
Publicado: (2020)

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
por: Khandazhinskaya, Anastasia L., et al.
Publicado: (2019)

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues
por: Guinan, Mieke, et al.
Publicado: (2020)

Synthetic strategies toward 1,3-oxathiolane nucleoside analogues
por: Aher, Umesh P, et al.
Publicado: (2021)

Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors
por: Kershaw, Neil M., et al.
Publicado: (2019)

Microwave-assisted organic synthesis of nucleoside ProTide analogues
por: Bordoni, Cinzia, et al.
Publicado: (2019)

Single-molecule fluorescence detection of a tricyclic nucleoside analogue
por: Samaan, George N., et al.
Publicado: (2020)

In vitro and in vivo antiplasmodial evaluation of sugar-modified nucleoside analogues
por: Bege, Miklós, et al.
Publicado: (2023)

Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide
por: Olsen, Cecilie Elisabeth, et al.
Publicado: (2022)

Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when Combined with a PCNA Targeting Peptide()
por: Gederaas, Odrun A., et al.
Publicado: (2014)

Non-Nucleoside Inhibitors Decrease Foot-and-Mouth Disease Virus Replication by Blocking the Viral 3D(pol)
por: Theerawatanasirikul, Sirin, et al.
Publicado: (2022)

Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
por: Petrovic, Voin, et al.
Publicado: (2018)

“Two hits - one stone”; increased efficacy of cisplatin-based therapies by targeting PCNA’s role in both DNA repair and cellular signaling
por: Søgaard, Caroline Krogh, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_76cmj4slqsk1g1oqsp47odaorl