PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials

Messenger RNA (mRNA) delivery strategies are required to protect biologically fragile mRNA from ribonuclease (RNase) attacks to achieve efficient therapeutic protein expression. To tackle this issue, most mRNA delivery systems have used cationic components, which form electrostatically driven comple...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshinaga, Naoto, Naito, Mitsuru, Tachihara, Yoshihiro, Boonstra, Eger, Osada, Kensuke, Cabral, Horacio, Uchida, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227728/
https://www.ncbi.nlm.nih.gov/pubmed/34071840
http://dx.doi.org/10.3390/pharmaceutics13060800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227728/
https://www.ncbi.nlm.nih.gov/pubmed/34071840
http://dx.doi.org/10.3390/pharmaceutics13060800

Ejemplares similares