Cargando…

PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials

Messenger RNA (mRNA) delivery strategies are required to protect biologically fragile mRNA from ribonuclease (RNase) attacks to achieve efficient therapeutic protein expression. To tackle this issue, most mRNA delivery systems have used cationic components, which form electrostatically driven comple...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoshinaga, Naoto, Naito, Mitsuru, Tachihara, Yoshihiro, Boonstra, Eger, Osada, Kensuke, Cabral, Horacio, Uchida, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227728/ https://www.ncbi.nlm.nih.gov/pubmed/34071840 http://dx.doi.org/10.3390/pharmaceutics13060800

Ejemplares similares

PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration
por: Kurimoto, Shota, et al.
Publicado: (2019)

Polymeric Micelles with pH-Responsive Cross-Linked Core Enhance In Vivo mRNA Delivery
por: Yang, Wenqian, et al.
Publicado: (2022)

Translation of human Δ133p53 mRNA and its targeting by antisense oligonucleotides complementary to the 5′-terminal region of this mRNA
por: Żydowicz-Machtel, Paulina, et al.
Publicado: (2021)

Nonsense-mediated mRNA decay uses complementary mechanisms to suppress mRNA and protein accumulation
por: Udy, Dylan B, et al.
Publicado: (2021)

Inhibitory Effect of Phosphorothioate Oligonucleotide Complementary to G6PD mRNA on Murine Melanoma
por: Yurchenko, Kseniya A., et al.
Publicado: (2023)

Target mRNA inhibition by oligonucleotide drugs in man
por: Lightfoot, Helen L., et al.
Publicado: (2012)

The effects of PEGylation on LNP based mRNA delivery to the eye
por: Ryals, Renee C., et al.
Publicado: (2020)

Modeling the effect of rRNA-mRNA interactions and mRNA folding on mRNA translation in chloroplasts
por: Carmel Ezra, Stav, et al.
Publicado: (2022)

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides
por: Gill, Taylor, et al.
Publicado: (2021)

mRNA–mRNA duplexes that auto-elicit Staufen1-mediated mRNA decay
por: Gong, Chenguang, et al.
Publicado: (2013)

mRNA as a Therapeutics: Understanding mRNA Vaccines
por: Oğuz, Ferdi, et al.
Publicado: (2022)

mRNA Vaccine Platform: mRNA Production and Delivery
por: Litvinova, V. R., et al.
Publicado: (2023)

PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA
por: Xu, Yingying, et al.
Publicado: (2023)

mRNA analysis of single living cells
por: Osada, Toshiya, et al.
Publicado: (2003)

Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
por: Grabowska-Pyrzewicz, Wioleta, et al.
Publicado: (2021)

Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay
por: Nomakuchi, Tomoki T., et al.
Publicado: (2015)

Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotides
por: Ham, Kristin A., et al.
Publicado: (2021)

RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
por: Chattopadhyay, Shiladitya, et al.
Publicado: (2022)

mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations
por: Carreño, Juan Manuel, et al.
Publicado: (2022)

An Oligonucleotide-based Tandem RNA Isolation Procedure to Recover Eukaryotic mRNA-Protein Complexes
por: Iadevaia, Valentina, et al.
Publicado: (2018)

Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via π–π stacking-assisted micellar assembly
por: Yang, Wenqian, et al.
Publicado: (2023)

Isolation of mRNA from specific tissues of Drosophila by mRNA tagging
por: Yang, Zhiyong, et al.
Publicado: (2005)

Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA
por: Asrani, Kirtika H., et al.
Publicado: (2018)

mRNA vaccines: the most recent clinical applications of synthetic mRNA
por: Kwon, Suji, et al.
Publicado: (2022)

Myocarditis following COVID‐19 mRNA (mRNA‐1273) vaccination
por: Chellapandian, Suresh Babu, et al.
Publicado: (2022)

mRNA ageing shapes the Cap2 methylome in mammalian mRNA
por: Despic, Vladimir, et al.
Publicado: (2023)

Synthetic mRNA-based gene therapy for glioblastoma: TRAIL-mRNA synergistically enhances PTEN-mRNA-based therapy
por: Tang, Xiangjun, et al.
Publicado: (2022)

A Complementary Mechanism of Bacterial mRNA Translation Inhibition by Tetracyclines
por: Barrenechea, Victor, et al.
Publicado: (2021)

Selection of antisense oligonucleotides based on multiple predicted target mRNA structures
por: Bo, Xiaochen, et al.
Publicado: (2006)

Stability of mRNA/DNA and DNA/DNA Duplexes Affects mRNA Transcription
por: Kraeva, Rayna I., et al.
Publicado: (2007)

Assembly of mRNA-Protein Complexes for Directional mRNA Transport in Eukaryotes - An Overview
por: Jansen, Ralf-Peter, et al.
Publicado: (2012)

Nuclear mRNA maturation and mRNA export control: from trypanosomes to opisthokonts
por: Kramer, Susanne
Publicado: (2021)

Advancements of in vitro transcribed mRNA (IVT mRNA) to enable translation into the clinics
por: Kang, Diana D., et al.
Publicado: (2023)

Variability of eliciting thresholds in PEG allergy limits prediction of tolerance to PEG-containing mRNA COVID vaccines
por: Mathes, Sonja, et al.
Publicado: (2022)

A graveyard for mRNA
por: Wells, William A.
Publicado: (2003)

Sorting the mRNA overflow
por: LeBrasseur, Nicole
Publicado: (2005)

New mRNA modification?
por: Leslie, Mitch
Publicado: (2007)

Localized mRNA is the norm
por: Sedwick, Caitlin
Publicado: (2007)

Sensitivity of mRNA Translation
por: Poker, Gilad, et al.
Publicado: (2015)

Synthetic mRNA capping
por: Muttach, Fabian, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3u0827gr2pq0of8h094tu6ntn5